Influence of the fragility profile on the health condition of patients with breast cancer
Keywords:
Frailty, Neoplasm, MortalityAbstract
The frailty has the potential to affect any aspect of an individual's life, can overwhelm not only the affected person, but the family, caregivers and health service costs. The Frailty can be established as a clinical syndrome, multifactorial etiology, characterized by the decline of energy reserves, resistance, conditions that respond to the decline of physiological systems. The neoplasm causes several weaknesses for the affected patient, for several factors, mainly due factors that the therapeutic modalities used can be aggressive. In view of this, several points are highlighted, but mainly that, patients who were frail, showed accelerated mortality rates as early as one year after diagnosis, whereas those who were pre-frail did not have such a large number, but obtained rates of higher mortality than those who were robust. Given the present work, it aims to explore, describe and discuss the influence of the frailty profile of patients with breast cancer on their health conditions. Assessing the frailty profile of patients with breast cancer is necessary. And the therapeutic conduct must be individualized, more importantly, assessing frailty (do not treat) is essential to know the risk-benefit profile and the well-informed willingness of the patient to be treated. With this, we found that it is of paramount importance to assess the frailty profile in the health status and treatment of cancer patients.
References
ANDRADE, A. N. et al. Análise do conceito fragilidade em idosos. Texto & Contexto-Enfermagem, v. 21, p. 748-756, 2012.
FREITAS, C. V. et al. Avaliação de fragilidade, capacidade funcional e qualidade de vida dos idosos atendidos no ambulatório de geriatria de um hospital universitário. Revista Brasileira de Geriatria e Gerontologia, v. 19, p. 119-128, 2016.
FRIED, L. P. et al. Frailty in older adults: evidence for a phenotype. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, v. 56, n. 3, p. M146-M157, 2001.
GROSS, C. B. et al. Níveis de fragilidade de idosos e sua associação com as características sociodemográficas. Acta Paulista de Enfermagem, v. 31, p. 209-216, 2018.
INSTITUTO NACIONAL DE C NCER (INCA). Estatísticas de câncer. INCA, 2022. Disponível em: https://www.inca.gov.br/numeros-de-cancer. Acesso em: 29 mar. 2022.
KIM, D. Y. et al. Cardiovascular outcome of breast cancer patients with concomitant radiotherapy and chemotherapy: A 10-year multicenter cohort study. Journal of Cardiology, v. 74, n. 2, p. 175–181, 2019.
MANDELBLATT, J. S. et al. Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance). Breast Cancer Research and Treatment, v. 164, p. 107-117, 2017.
NASCIMENTO, L. C.; ANDRADE, L. D. F. Importância da assistência de enfermagem no tratamento do câncer de mama frente às fragilidades e desafios do tratamento. In: Congresso Brasileiro de Ciências da Saúde. 2018.
SILVA, S. L. A. et al. Fenótipo de fragilidade: influência de cada item na determinação da fragilidade em idosos comunitários–Rede Fibra. Ciência & Saúde Coletiva, v. 21, p. 3483-3492, 2016.
TIGRE, A. Educação em saúde: Práticas de uma equipe multiprofissional na atenção ao paciente oncológico em quimioterapia. 2017.
OSÓRIO, F. et al. Frailty-independent undertreatment negative impact on survival in older patients with breast cancer. Journal of Breast Cancer, v. 24, n. 6, p. 542, 2021.
FELICIANO, E. M. C. et al. Association of prediagnostic frailty, change in frailty status, and mortality after cancer diagnosis in the Women’s Health Initiative. JAMA network open, v. 3, n. 9, p. e2016747, 2020.
BERBEN, L. et al. Blood immunosenescence signatures reflecting age, frailty and tumor immune infiltrate in patients with early luminal breast cancer. Cancers, v. 13, n. 9, p. 2185, 2021.
BAILUR, J. K. et al. Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty. Breast Cancer Research, v. 19, n. 1, p. 1-10, 2017.
BELLIENI, A. et al. Different impact of definitions of sarcopenia in defining frailty status in a population of older women with early breast cancer. Journal of Personalized Medicine, v. 11, n. 4, p. 243, 2021.
